Background: Hypertension is the most menacing disorder in Ayurveda. Prognosis of diseases can be identified by Concept of Prakriti (human constitution). Therefore in this study, we intend to study Pradhana sharira and Manas prakriti (dominant bodily and mental constitution) in Hypertension. On the basis of manifestation of sign and symptoms and current evidences Hypertension can be equated to Raktapradoshaja vikara. Methods: The specific research proforma was made to assess Sharira–manasa prakriti. Prakriti determination proforma was prepared having Vatika, Paitika and Kaphaja characters with reference to anatomical, physiological and sociological characters, by following Brihatrayi (Charaka, Sushruta and Ashtanga Hridaya). Prakriti of 103 subjects of Hypertension was assessed as per Sharirika (bodily humors) and Manasika prakriti assessment proforma which were analyzed according to characteristics found in subjects. Results: Maximum 60.78 % subjects were having Rajas Pradhana prakriti and maximum 50 % having Rajas Pradhana prakriti. 53.92 % were in age group of 36-55 years, 6 Rajas Pradhana prakriti 6.67 % patients were male, 97.06 % patients were Hindu, majority of patients i.e. 98.04 % were married, 64.71 % patients were have sitting occupation, 98.04 % patients were educated, maximum No. of patients i.e. 89.22 % were from middle class. In Rajas Pradhana prakriti lakshana, Kama found in 67.65 % and in Tamas Pradhana prakriti lakshana, Buddhinirodha was found in 82.35 %. Conclusion: Sharira and Manasa bhava play an important role in manifestation of Hypertension. Therefore, it can be said that dominant Pitta and Rajas prakriti may have influence on manifestation of Hypertension.