Comparative Antipyretic Effect of Nagaradi Kwatha, Ghana Vati and Arishta in Wistar Albino Rats
Introduction: Kwatha (Decoction) kalpana is one amongst the basic preparations in herbal pharmaceutics. Marketing these formulations is not possible because of its shorter shelf life and hence Nagaradi Kwatha is converted to Arishta (fermented product of decoction) and Ghana vati (solidified aqueous extract) form by using the method of Anukta paribhasha explained in the classical texts of Ayurveda. Nagaradi Kwatha is widely used in clinical practice as Jwaraghna (antipyretic). Nagara, Haritaki and Guduchi are the main ingredients, which helps in ama pachana here by relieves Jwara (fever). Methods: The pyrexia was induced by subcutaneous injection of 20% of Brewer’s yeast solution at a dose of 1ml/100g body weight. The group specific drugs were administered after 18th hour of yeast injection. The rectal temperatures were recorded by using digital Telethermometer before yeast injection and at hourly interval for 4 hours, 24 h after the yeast injection. Results: The results are significant indicators of the anti-pyretic activity of Nagaradi combination. The Arishta form of Nagaradi combination was significantly decreased the rectal temperature measured at 1st, 3rd, 4th and 24h after fever induction. Conclusion: It can be concluded that the Arishta form has better antipyretic effect than Kwatha and Ghana vati form of Nagaradi combination.