Pharmaceutical Standardization of Guggulu Sodhana

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Journal of Ayurveda Medical Sciences,2017,2,2,165-173.
Published:April 2017
Type:Original Article
Author(s) affiliations:

Kruti Yagneshkumar Vyas,1* Vinay Janaradan Shukla,2 Galib Ruknuddin,3 Pradeep Kumar Prajapati4

1Department of Rasa Shastra and Bhaishajya Kalpana, Shri OH Nazar Ayurveda Mahavidhyalaya, Surat, Gujarat 395003, India.

2Pharmaceutical Chemistry Laboratory, Institute for Post Graduate Teaching & Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat 361008, India.

3,4Department of Rasa Shastra and Bhaishajya Kalpana, All India Institute of Ayurveda, New Delhi 110076, India.


Introduction: Śodhana is a preliminary process that helps in eliminating possible physical or chemical blemishes from raw material and making them suitable for therapeutic application. Guggulu (Commiphora wightii (Arn) Bhandari) is a well-known herb in Āyurveda, which is gaining its attention in world market. Exudate of the plant is therapeutically active and need to process before it is converted into formulations. As a little data is available on standard manufacturing procedure of Guggulu Śodhana; the current attempt is planned to evaluate the same. Methods: Guggulu was procured from Gujarat state forest department corp. Ltd., Vadodara. Śodhana was done in 10 batches in Gomūtra. Organoleptic characters, loss on drying, ash value, acid insoluble ash, water soluble extractives, methanol soluble extractives, pH and volatile oil content, HPTLC, HPLC, FTIR, Heavy metal analysis and Microbial over load were carried out. Results: Average 80.56% yield was observed after Śodhana. Differences were found in physico-chemical, HPLC and FTIR analysis that show the impact of Śodhana procedure on Guggulu. Conclusion: The adopted method for Guggulu Śodhana can be considered as easy, convenient and standard procedure and the values of physico-chemical parameters may be taken for quality assurance.